Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD)

• The Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD) Test is a critical screening test performed on newborns to detect G6PD deficiency, a genetic condition that affects red blood cells
• G6PD is an enzyme that helps protect red blood cells from damage
• A deficiency in G6PD can lead to hemolytic anemia, especially when the infant is exposed to certain foods, medications, or infections
• The Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD) Test is typically part of a routine newborn screening panel, ensuring early detection and management to prevent complications

• Early Detection of G6PD Deficiency: Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD) Test identifies newborns at risk for hemolytic anemia due to G6PD deficiency
• Preventing Complications: Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD) Test helps in taking preventive measures to avoid triggers that can cause red blood cell breakdown
• Genetic Counseling: Newborn Screening Glucose-6-Phosphate Dehydrogenase (G6PD) Test assists parents in understanding the inheritance pattern and risks for future pregnancies

• Sample Collection: A small blood sample, usually taken from the baby’s heel (heel prick), is collected shortly after birth
• Analysis: The blood sample is analyzed to determine the activity level of the G6PD enzyme
• Results: The enzyme activity level is reported, indicating whether the newborn has a normal G6PD level or a deficiency

• Normal G6PD Levels: Indicate the baby has normal enzyme activity and is not at risk for G6PD deficiency-related complications
• Low G6PD Levels: Suggest a deficiency in the enzyme, putting the baby at risk for hemolytic anemia, especially when exposed to certain triggers
• Very Low G6PD Levels: Indicate a severe deficiency, requiring immediate medical attention and careful management to avoid complications

• Reference Range: Normal enzyme levels vary but are typically within a specific range provided by the laboratory
• Positive Result (Deficiency): Indicates the need for further testing and immediate preventive measures to avoid hemolysis
• Negative Result (Normal): Suggests that the baby does not have G6PD deficiency and no further action is needed regarding this condition

Q. What is the G6PD test in newborn screening?
The G6PD test checks if a newborn has a deficiency in the G6PD enzyme, which can lead to hemolytic anemia

Q. Why is this test important for my baby?
Early detection of G6PD deficiency can help prevent serious health issues by avoiding triggers that cause red blood cell breakdown

Q. How is the test done?
A small blood sample is taken from your baby's heel and tested for G6PD enzyme levels

Q. What does a positive G6PD test mean?
A positive test indicates that your baby has G6PD deficiency, which means their red blood cells can break down more easily under certain conditions

Q. Is G6PD deficiency common?
G6PD deficiency is one of the most common enzyme deficiencies worldwide, particularly in certain ethnic groups

Q. What should I do if my baby has G6PD deficiency?
Your doctor will guide you on how to avoid triggers like certain foods, medications, and infections that could cause red blood cell breakdown

Q. Can G6PD deficiency be cured?
There is no cure for G6PD deficiency, but with proper management, most children with the condition can lead healthy lives