Metanephrines Fractionated 24 Hours Urine

• The Metanephrines Fractionated 24-hour Urine Test is a diagnostic laboratory examination designed to measure the levels of metanephrines in a patient's urine over 24 hours
• Metanephrines are metabolites of catecholamines, such as adrenaline and noradrenaline, and their measurement aids in the diagnosis and monitoring of certain adrenal gland disorders, particularly pheochromocytomas and paragangliomas

• Detection of Adrenal Tumors: The test is crucial in identifying and diagnosing adrenal tumours, including pheochromocytomas and paragangliomas
• Monitoring Treatment: It helps monitor the effectiveness of treatment in patients with known adrenal tumours
• Confirmation of Diagnosis: The test is employed to confirm or rule out the presence of excess catecholamine production associated with adrenal tumours
• Risk Assessment: Individuals with a family history of adrenal tumours or certain genetic conditions may undergo this test to assess their risk

• The test involves the collection of urine over 24 hours, during which the patient is required to abstain from specific foods and activities
• The collected urine is then analyzed to measure the levels of metanephrines, including metanephrine and normetanephrine

• Normal Levels: Normal results indicate that the patient is not likely to have an adrenal tumor
• Elevated Levels: Elevated levels of metanephrines may suggest the presence of a pheochromocytoma or paraganglioma
• Confirmation of Diagnosis: Results are often interpreted in conjunction with clinical findings and imaging studies to confirm or exclude the diagnosis of adrenal tumors

• The results are reported as the concentration of metanephrines (metanephrine and normetanephrine) in micrograms per 24 hours.
• The healthcare provider interprets the results in the context of the patient's medical history, symptoms, and other diagnostic tests to make a comprehensive assessment

Q: Why is the 24-hour urine collection necessary for this test?
The 24-hour collection allows for a more accurate assessment of metanephrine levels throughout the day, providing a comprehensive picture of adrenal function
 

Q: Are there any dietary restrictions before the test?
Yes, patients are typically advised to avoid certain foods and medications that may interfere with test results, such as caffeine and certain medications
 

Q: Can medications affect the test results?
Yes, some medications, including certain antihypertensive drugs, may interfere with the accuracy of metanephrine measurements
 

Q: How often should the test be repeated for monitoring purposes?
The frequency of testing for monitoring purposes is determined by the healthcare provider based on the patient's condition and treatment plan
 

Q: Can stress affect metanephrine levels?
Stressful situations can temporarily elevate metanephrine levels; therefore, patients are advised to follow specific pre-test guidelines to minimize external factors
 

Q: Is the test painful or invasive?
No, the test involves urine collection only and is not painful or invasive
 

Q: Can conditions other than adrenal tumours cause elevated metanephrines?
While adrenal tumours are the primary concern, certain medications and other medical conditions can also contribute to elevated metanephrine levels, necessitating a thorough evaluation by a healthcare professional