HLA-B*1502

• The HLA-B*1502 Test is a genetic test used to detect the presence of the HLA-B1502 allele, a specific variant of the HLA-B gene
• This HLA-B*1502 Test is crucial for identifying individuals who are at increased risk of severe adverse reactions to certain medications, such as carbamazepine and phenytoin, which are commonly used to treat epilepsy and other neurological conditions
• The presence of the HLA-B*1502 allele is strongly associated with a higher risk of developing Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), both of which are life-threatening skin conditions

• HLA-B*1502 Test identify individuals at risk for severe drug reactions, particularly to carbamazepine and phenytoin
• HLA-B*1502 Test guide safe and effective medication choices for patients, especially those of Asian descent where the HLA-B*1502 allele is more prevalent
• HLA-B*1502 Test prevent severe adverse drug reactions by pre-screening patients before initiating treatment with high-risk medications
• HLA-B*1502 Test provide personalized medical care based on genetic makeup

• Collection of a blood or cheek swab sample
• DNA extraction and analysis to detect the presence of the HLA-B*1502 allele
• A comprehensive report detailing the presence or absence of the HLA-B*1502 allele

• Positive Result: Indicates the presence of the HLA-B*1502 allele, suggesting a higher risk of severe adverse reactions to carbamazepine and phenytoin. Alternative medications should be considered
• Negative Result: Indicates the absence of the HLA-B*1502 allele, suggesting a lower risk of adverse reactions to these medications. However, other factors should still be considered when prescribing

• The presence or absence of the HLA-B*1502 allele
• Clinical interpretation of the genetic findings to drug safety
• Recommendations for medication choices and management based on the genetic results

Q. What is the HLA-B*1502 Test?
This HLA-B*1502 Test checks if you have the HLA-B*1502 allele, which can indicate a higher risk of severe skin reactions to certain medications like carbamazepine and phenytoin

Q. Why do I need the HLA-B*1502 Test?
If you are going to be treated with carbamazepine or phenytoin, this test helps determine if you are at risk for severe adverse reactions to these drugs

Q. How is the HLA-B*1502 Test performed?
A blood sample or cheek swab is collected and analyzed in a lab to detect the presence of the HLA-B*1502 allele

Q. What does a positive result mean on the HLA-B*1502 Test?
A positive result means you have the HLA-B*1502 allele, indicating a higher risk of severe reactions to certain medications. Your doctor may choose alternative treatments

Q. Can a negative result completely rule out all drug reactions?
No, a negative result means you don't have the HLA-B*1502 allele, but it doesn't rule out other potential drug reactions. Always discuss medication risks with your doctor

Q. Do I need to prepare for the HLA-B*1502 Test?
No special preparation is needed, but follow any specific instructions from your doctor

Q. How long does it take to get the results?
Results are typically available within a few days to a couple of weeks after the sample is collected and analyzed