Antineutrophil Cytoplasmic Antibodies (ANCA) IFA

• The Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test is a diagnostic blood test used to detect ANCAs, which are autoantibodies directed against proteins in the cytoplasm of neutrophils
• The Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test uses Indirect Immunofluorescence Assay (IFA) to identify the presence and pattern of these antibodies, helping in the diagnosis of certain autoimmune disorders, especially vasculitis

• To diagnose and monitor autoimmune vasculitis, such as Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)
• To differentiate between types of vasculitis and other autoimmune diseases
• To guide treatment decisions and monitor the effectiveness of therapy for vasculitis

• Collection of a blood sample
• Use of Indirect Immunofluorescence Assay (IFA) to detect ANCAs
• Identification of ANCA patterns, such as cytoplasmic (c-ANCA) or perinuclear (p-ANCA), which are associated with specific types of vasculitis

• Positive c-ANCA: Typically associated with Granulomatosis with Polyangiitis (GPA)
• Positive p-ANCA: Often linked to Microscopic Polyangiitis (MPA) and other autoimmune conditions
• Negative ANCA: May indicate the absence of autoimmune vasculitis or require further investigation if symptoms persist

• Positive Result: Presence of ANCAs indicates an autoimmune response, suggesting vasculitis or another autoimmune disease
• Negative Result: Absence of detectable ANCAs, though further tests may be needed if clinical suspicion remains high

Q. What is the Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test?
Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test is a blood test that detects antibodies against proteins in neutrophils, helping diagnose certain autoimmune diseases

Q. Why do I need the Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test?
To diagnose or monitor autoimmune vasculitis and other related conditions

Q. How is the Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test performed?
A blood sample is taken from your vein and analyzed using immunofluorescence to detect ANCA antibodies

Q. What does a positive c-ANCA result mean?
Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test typically indicates Granulomatosis with Polyangiitis (GPA), a type of autoimmune vasculitis

Q. What does a positive p-ANCA result mean?
It is often associated with Microscopic Polyangiitis (MPA) and other autoimmune disorders

Q. Can I have vasculitis if my ANCA IFA test is negative?
Yes, a negative result doesn't rule out vasculitis completely; other tests may be needed based on symptoms

Q. hat should I do if my Antineutrophil Cytoplasmic Antibodies (ANCA) IFA Test is positive?
Consult your doctor for further evaluation and to discuss appropriate treatment options